GeneID = 8989 is in our transporter list.
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  • Gene general annotation
  • Data comes from NCBI-Gene
    Entrez GeneID 8989
    Gene Symbol TRPA1
    Aliases ANKTM1
    Description transient receptor potential cation channel, subfamily A, member 1
    Organism Homo sapiens
    Location 8q13
    Genomic position NC_000008.10 72933485-72987818 minus strand (Reference GRCh37.p5 Primary Assembly) U E
    UniProt Accession O75762
    Mammalian Homolog
    (GeneID)
    mouse : 277328
    rat : 312896
  • KOBAS Annotation (Pathway/Disease Annotation)
  • PharmacoGenetics Related Genes/Drugs/Diseases
  • TaxicoGenetics Related Chemicals/Diseases/Pathways
  • Known Drugs in DrugBank
  • Data comes from DrugBank
    DrugBank DrugIDDrug NameRelated UniProt AccessionGene TypeAction
    DB00825 Menthol O75762 target inducer
  • Transporter Substrate Information
  • Data comes from (unpublished integrated data)
    KEGG Compound ID:
    C01373
  • Genomic Variation --- SNP
  • Data is integrated from dbSNP and HapMap, with functionally annotated by ANNOVAR
    Note: heterozygosity is not actually estimated from 1KG data, but is put in the same line for more compact representation.
    dbSNP rsIDchrpositionpop.alleleallele countfrequencyHapMap pop. diff.genotypegenotype count (frequency) functional annotation
    rs957524 8 72935993 CEU A / G 123 / 5 FET lg p = -1.26

    max diff AF = 0.039
    A/A / A/G / G/G 59 / 5 / 0 ncRNA_intronic: LOC100132891
    CHB 90 / 0 45 / 0 / 0
    JPT 90 / 0 45 / 0 / 0
    YRI 112 / 4 55 / 2 / 1
    1KG G (minor)59 in 2178 = 0.02709 heterozygosity = 0.05271, with SE = 0.15355
    rs957299 8 72950083 CEU T / G 130 / 0 FET lg p = 0.00

    max diff AF = 0.000
    T/T / G/T / G/G 65 / 0 / 0 ncRNA_intronic: LOC100132891
    CHB 90 / 0 45 / 0 / 0
    JPT 90 / 0 45 / 0 / 0
    YRI 126 / 0 63 / 0 / 0
    1KG heterozygosity = 0.00000, with SE = 0.00000
    rs920830 8 72977519 CEU G / A 73 / 57 FET lg p = -18.27

    max diff AF = 0.427
    G/G / A/G / A/A 18 / 37 / 10 intronic: TRPA1
    CHB 89 / 1 44 / 1 / 0
    JPT 86 / 4 41 / 4 / 0
    YRI 109 / 17 48 / 13 / 2
    1KG A (minor)475 in 2178 = 0.21809 heterozygosity = 0.34105, with SE = 0.23283
    rs920829 8 72977703 ASW C / T 81 / 33 FET lg p = -23.87

    max diff AF = 0.302
    C/C / C/T / T/T 28 / 25 / 4 exonic: TRPA1

    nonsynonymous SNV: TRPA1, NM_007332, exon4, c.G535A, p.E179K

    SIFT score = 0.07

    PolyPhen2 score = 0.85
    CEU 188 / 32 79 / 30 / 1
    CHB 184 / 84 64 / 56 / 14
    CHD 137 / 75 41 / 55 / 10
    GIH 171 / 27 74 / 23 / 2
    JPT 144 / 78 47 / 50 / 14
    LWK 140 / 80 43 / 54 / 13
    MEX 107 / 7 51 / 5 / 1
    MKK 224 / 88 78 / 68 / 10
    TSI 176 / 20 78 / 20 / 0
    YRI 185 / 95 62 / 61 / 17
    1KG T (minor)457 in 2178 = 0.20983 heterozygosity = 0.33160, with SE = 0.23631
    rs920828 8 72978946 CHB A / T 90 / 0 FET lg p = 0.00

    max diff AF = 0.000
    A/A / A/T / T/T 45 / 0 / 0 intronic: TRPA1
    JPT 90 / 0 45 / 0 / 0
    YRI 122 / 0 61 / 0 / 0
    1KG T (minor)477 in 2178 = 0.21901 heterozygosity = 0.34209, with SE = 0.23242
    Limited to 5 records in this page. Click here to view more.
  • Genomic Variation --- CNV
  • Data comes from DGV
    Variation IDPositionVar. TypeGainLossTotal GL InvPubMed
    Variation_60712 chr8:72947782-72947931 U E InDel 1 0 1 19470904
  • Haplotype Information
  • Data links to UCSC Genome Browser
    ContentHyperlinkDemo example
    HapMap LD Structure (hg18)UCSC
    1000 Genomes Phase I Haplotype Clustering (hg19)UCSC
    Gene Haplotype Allele (hg19)UCSC
  • ENCODE TFBS (Transcription Factor Binding Sites) Information
  • Epigenetic Information
  • Gene Ontology (GO)
  • Protein Sequence & Features
  • Protein Domain Information
  • Protein-Protein Interaction
  • UniGene EST Expression Data
  • Allen Brain Atlas - Mouse Brain Expression Data
  • RNA-seq Expression Data
  • External Links
  • EntrezGeneID 8989
    Gene Symbol and
    Genome Browser
    TRPA1
    UCSC Ensembl
    mRNA NM_007332
    protein NP_015628
    Ensembl ENST00000262209; ENSP00000262209; ENSG00000104321
    HPRD 09208
    UniProt Accession O75762
    GeneCards GC08M072983
    UniGene Hs.716816
    HomoloGene 7189
    EMBL Y10601; AC022867
    IPI IPI00015963
    PRIDE O75762
    STRING O75762
    TCDB 1.A.4.6.3
    OMIM 604775