GeneID = 7224 is in our transporter list.
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  • Gene general annotation
  • Data comes from NCBI-Gene
    Entrez GeneID 7224
    Gene Symbol TRPC5
    Aliases TRP5
    Description transient receptor potential cation channel, subfamily C, member 5
    Organism Homo sapiens
    Location Xq23
    Genomic position NC_000023.10 111017541-111326003 minus strand (Reference GRCh37.p5 Primary Assembly) U E
    UniProt Accession Q9UL62
    Mammalian Homolog
    (GeneID)
    mouse : 22067
    rat : 140933
  • KOBAS Annotation (Pathway/Disease Annotation)
  • Data comes from KOBAS
    Pathway IDPathway NamePathway Database
    P00004 Alzheimer disease-presenilin pathway PANTHER
    REACT:18266 Axon guidance Reactome
    Disease IDDisease NameDisease Database
    1781 Rheumatoid arthritis FunDO
    1878 Ischemia FunDO
    CHEMDEPENDENCY GAD
    smoking behavior GAD
    Smoking behavior NHGRI
  • PharmacoGenetics Related Genes/Drugs/Diseases
  • Data comes from PharmGKB PA37010
    PharmGKB AccessionClassName / Gene Symbol (Entrez Gene ID)
    PA445876 Disease Tobacco Use Disorder
  • TaxicoGenetics Related Chemicals/Diseases/Pathways
  • Known Drugs in DrugBank
  • Transporter Substrate Information
  • Data comes from (unpublished integrated data)
    KEGG Compound ID:
    C00076
  • Genomic Variation --- SNP
  • Data is integrated from dbSNP and HapMap, with functionally annotated by ANNOVAR
    Note: heterozygosity is not actually estimated from 1KG data, but is put in the same line for more compact representation.
    dbSNP rsIDchrpositionpop.alleleallele countfrequencyHapMap pop. diff.genotypegenotype count (frequency) functional annotation
    rs886851 X 111100635 CEU G / C 101 / 0 FET lg p = -24.81

    max diff AF = 0.459
    G/G / C/G / C/C 65 / 0 / 0 intronic: TRPC5
    CHB 68 / 0 45 / 0 / 0
    JPT 66 / 0 44 / 0 / 0
    YRI 53 / 45 25 / 19 / 19
    1KG C (minor)168 in 1654 = 0.10157 heterozygosity = 0.18251, with SE = 0.24072
    rs758030 X 111101179 CEU C / A 101 / 0 FET lg p = 0.00

    max diff AF = 0.000
    C/C / A/C / A/A 65 / 0 / 0 intronic: TRPC5
    CHB 68 / 0 45 / 0 / 0
    JPT 66 / 0 44 / 0 / 0
    YRI 98 / 0 63 / 0 / 0
    1KG A (minor)0 in 1654 = 0.00000 heterozygosity = 0.00000, with SE = 0.00000
    rs740357 X 111160693 CEU T / G 89 / 12 FET lg p = -50.55

    max diff AF = 0.643
    T/T / G/T / G/G 54 / 5 / 6 intronic: TRPC5
    CHB 218 / 1 135 / 0 / 1
    CHD 167 / 1 108 / 0 / 1
    GIH 137 / 7 94 / 3 / 4
    JPT 66 / 0 44 / 0 / 0
    MEX 82 / 2 54 / 0 / 2
    TSI 126 / 19 82 / 4 / 13
    YRI 35 / 63 14 / 17 / 32
    1KG G (minor)331 in 1654 = 0.20012 heterozygosity = 0.32015, with SE = 0.23996
    rs767034 X 111168829 CEU C / T 94 / 7 FET lg p = -17.41

    max diff AF = 0.327
    C/C / C/T / T/T 58 / 4 / 3 intronic: TRPC5
    CHB 68 / 0 45 / 0 / 0
    CHD 167 / 1 108 / 0 / 1
    GIH 141 / 3 98 / 0 / 3
    JPT 66 / 0 44 / 0 / 0
    MEX 82 / 2 54 / 0 / 2
    TSI 132 / 15 86 / 4 / 10
    YRI 66 / 32 34 / 16 / 13
    1KG T (minor)212 in 1654 = 0.12817 heterozygosity = 0.22349, with SE = 0.24859
    rs715154 X 111312215 CEU C / T 89 / 0 FET lg p = 0.00

    max diff AF = 0.000
    C/C / C/T / T/T 57 / 0 / 0 intronic: TRPC5
    CHB 61 / 0 40 / 0 / 0
    JPT 68 / 0 45 / 0 / 0
    YRI 90 / 0 57 / 0 / 0
    1KG T (minor)1 in 1654 = 0.00060 heterozygosity = 0.00121, with SE = 0.02456
    Limited to 5 records in this page. Click here to view more.
  • Genomic Variation --- CNV
  • Haplotype Information
  • Data links to UCSC Genome Browser
    ContentHyperlinkDemo example
    HapMap LD Structure (hg18)UCSC
    1000 Genomes Phase I Haplotype Clustering (hg19)UCSC
    Gene Haplotype Allele (hg19)UCSC
  • ENCODE TFBS (Transcription Factor Binding Sites) Information
  • Epigenetic Information
  • Gene Ontology (GO)
  • Protein Sequence & Features
  • Protein Domain Information
  • Protein-Protein Interaction
  • UniGene EST Expression Data
  • Allen Brain Atlas - Mouse Brain Expression Data
  • RNA-seq Expression Data
  • External Links
  • EntrezGeneID 7224
    Gene Symbol and
    Genome Browser
    TRPC5
    UCSC Ensembl
    mRNA NM_012471
    protein NP_036603
    Ensembl ENST00000262839; ENSP00000262839; ENSG00000072315
    HPRD 02273
    UniProt Accession Q9UL62
    GeneCards GC0XM111017
    UniGene Hs.657709
    HomoloGene 74915
    EMBL AF054568; AC005191; AL049563; AC005191; CH471120; BC137271; BC137274
    IPI IPI00007836
    PRIDE Q9UL62
    STRING Q9UL62
    TCDB 1.A.4.1.7
    OMIM 300334
    PharmGKB PA37010
    Reactome REACT_111045