GeneID = 3739 is in our transporter list.
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  • Gene general annotation
  • Data comes from NCBI-Gene
    Entrez GeneID 3739
    Gene Symbol KCNA4
    Aliases HBK4,HK1,HPCN2,HUKII,KCNA4L,KCNA8,KV1.4,PCN2
    Description potassium voltage-gated channel, shaker-related subfamily, member 4
    Organism Homo sapiens
    Location 11p14
    Genomic position NC_000011.9 30031287-30038576 minus strand (Reference GRCh37.p5 Primary Assembly) U E
    UniProt Accession P22459
    Mammalian Homolog
    (GeneID)
    mouse : 16492
    rat : 25469
  • KOBAS Annotation (Pathway/Disease Annotation)
  • PharmacoGenetics Related Genes/Drugs/Diseases
  • Data comes from PharmGKB PA207
    PharmGKB AccessionClassName / Gene Symbol (Entrez Gene ID)
    PA452249 Drug antiarrhythmics, class i and iii
  • TaxicoGenetics Related Chemicals/Diseases/Pathways
  • Known Drugs in DrugBank
  • Data comes from DrugBank
    DrugBank DrugIDDrug NameRelated UniProt AccessionGene TypeAction
    DB02299 Arginineamide P22459 target
  • Transporter Substrate Information
  • Data comes from (unpublished integrated data)
    KEGG Compound ID:
    C00238
  • Genomic Variation --- SNP
  • Data is integrated from dbSNP and HapMap, with functionally annotated by ANNOVAR
    Note: heterozygosity is not actually estimated from 1KG data, but is put in the same line for more compact representation.
    dbSNP rsIDchrpositionpop.alleleallele countfrequencyHapMap pop. diff.genotypegenotype count (frequency) functional annotation
    rs3802914 11 30033191 ASW G / A 84 / 30 FET lg p = -45.80

    max diff AF = 0.345
    G/G / A/G / A/A 33 / 18 / 6 exonic: KCNA4

    synonymous SNV: KCNA4, NM_002233, exon2, c.C1035T, p.G345G
    CEU 195 / 31 83 / 29 / 1
    CHB 266 / 6 130 / 6 / 0
    CHD 208 / 10 99 / 10 / 0
    GIH 169 / 33 72 / 25 / 4
    JPT 222 / 4 109 / 4 / 0
    LWK 162 / 58 58 / 46 / 6
    MEX 104 / 12 46 / 12 / 0
    MKK 240 / 72 92 / 56 / 8
    TSI 163 / 41 66 / 31 / 5
    YRI 186 / 106 61 / 64 / 21
    1KG A (minor)348 in 2178 = 0.15978 heterozygosity = 0.26850, with SE = 0.24932
    rs1323860 11 30035236 ASW A / G 64 / 50 FET lg p = -9.99

    max diff AF = 0.242
    A/A / A/G / G/G 16 / 32 / 9 intronic: KCNA4
    CEU 128 / 98 37 / 54 / 22
    CHB 190 / 84 63 / 64 / 10
    CHD 157 / 61 58 / 41 / 10
    GIH 129 / 73 43 / 43 / 15
    JPT 170 / 56 63 / 44 / 6
    LWK 128 / 92 35 / 58 / 17
    MEX 77 / 39 27 / 23 / 8
    MKK 174 / 138 46 / 82 / 28
    TSI 104 / 100 27 / 50 / 25
    YRI 152 / 142 38 / 76 / 33
    1KG G (minor)830 in 2178 = 0.38108 heterozygosity = 0.47172, with SE = 0.11550
    rs10835608 11 30036177 ASW C / T 82 / 32 FET lg p = -54.61

    max diff AF = 0.530
    C/C / C/T / T/T 30 / 22 / 5 intronic: KCNA4
    CEU 176 / 50 68 / 40 / 5
    CHB 113 / 161 21 / 71 / 45
    CHD 83 / 135 18 / 47 / 44
    GIH 129 / 73 42 / 45 / 14
    JPT 63 / 163 6 / 51 / 56
    LWK 159 / 61 57 / 45 / 8
    MEX 65 / 51 19 / 27 / 12
    MKK 204 / 108 65 / 74 / 17
    TSI 165 / 39 70 / 25 / 7
    YRI 200 / 94 70 / 60 / 17
    1KG T (minor)838 in 2178 = 0.38476 heterozygosity = 0.47344, with SE = 0.11214
    rs521068 11 30036714 1KG T (minor)422 in 2178 = 0.19376 heterozygosity = 0.31243, with SE = 0.24208 intronic: KCNA4
    rs534311 11 30036782 ASW C / T 99 / 15 FET lg p = -8.19

    max diff AF = 0.190
    C/C / C/T / T/T 43 / 13 / 1 intronic: KCNA4
    CEU 162 / 64 58 / 46 / 9
    CHB 195 / 79 68 / 59 / 10
    CHD 167 / 51 66 / 35 / 8
    GIH 163 / 39 65 / 33 / 3
    JPT 175 / 51 68 / 39 / 6
    LWK 187 / 33 78 / 31 / 1
    MEX 92 / 24 38 / 16 / 4
    MKK 256 / 56 106 / 44 / 6
    TSI 149 / 55 54 / 41 / 7
    YRI 265 / 29 119 / 27 / 1
    1KG T (minor)450 in 2178 = 0.20661 heterozygosity = 0.32785, with SE = 0.23757
    Limited to 5 records in this page. Click here to view more.
  • Genomic Variation --- CNV
  • Haplotype Information
  • Data links to UCSC Genome Browser
    ContentHyperlinkDemo example
    HapMap LD Structure (hg18)UCSC
    1000 Genomes Phase I Haplotype Clustering (hg19)UCSC
    Gene Haplotype Allele (hg19)UCSC
  • ENCODE TFBS (Transcription Factor Binding Sites) Information
  • Epigenetic Information
  • Gene Ontology (GO)
  • Protein Sequence & Features
  • Protein Domain Information
  • Protein-Protein Interaction
  • UniGene EST Expression Data
  • Allen Brain Atlas - Mouse Brain Expression Data
  • RNA-seq Expression Data
  • External Links
  • EntrezGeneID 3739
    Gene Symbol and
    Genome Browser
    KCNA4
    UCSC Ensembl
    mRNA NM_002233
    protein NP_002224
    Ensembl ENST00000328224; ENSP00000328511; ENSG00000182255
    HPRD 01444
    UniProt Accession P22459
    GeneCards GC11M029988
    UniGene Hs.592002
    HomoloGene 20514
    EMBL M55514; M60450; L02751; AC124657
    PIR A39922; A39922
    IPI IPI00304582
    PRIDE P22459
    STRING P22459
    OMIM 176266
    PharmGKB PA207
    Reactome REACT_13685