GeneID = 23539 is in our transporter list.
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  • Gene general annotation
  • Data comes from NCBI-Gene
    Entrez GeneID 23539
    Gene Symbol SLC16A8
    Aliases MCT3,REMP
    Description solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
    Organism Homo sapiens
    Location 22q12.3-q13.2
    Genomic position NC_000022.10 38474143-38479169 minus strand (Reference GRCh37.p5 Primary Assembly) U E
    UniProt Accession O95907
    Mammalian Homolog
    (GeneID)
    mouse : 57274
    rat : 65200
  • KOBAS Annotation (Pathway/Disease Annotation)
  • PharmacoGenetics Related Genes/Drugs/Diseases
  • TaxicoGenetics Related Chemicals/Diseases/Pathways
  • Known Drugs in DrugBank
  • Data comes from DrugBank
    DrugBank DrugIDDrug NameRelated UniProt AccessionGene TypeAction
    DB00119 Pyruvic acid O95907 target
  • Transporter Substrate Information
  • Data comes from (unpublished integrated data)
    KEGG Compound ID:
    C00022C00033C00060C00164C01432
    C16434C16436C16439
  • Genomic Variation --- SNP
  • Data is integrated from dbSNP and HapMap, with functionally annotated by ANNOVAR
    Note: heterozygosity is not actually estimated from 1KG data, but is put in the same line for more compact representation.
    dbSNP rsIDchrpositionpop.alleleallele countfrequencyHapMap pop. diff.genotypegenotype count (frequency) functional annotation
    rs2076371 22 38474696 ASW G / A 106 / 8 FET lg p = -41.96

    max diff AF = 0.361
    G/G / A/G / A/A 49 / 8 / 0 exonic: SLC16A8

    synonymous SNV: SLC16A8, NM_013356, exon5, c.T1214T, p.V405V
    CEU 167 / 57 61 / 45 / 6
    CHB 258 / 16 122 / 14 / 1
    CHD 205 / 13 96 / 13 / 0
    GIH 129 / 73 41 / 47 / 13
    JPT 189 / 37 79 / 31 / 3
    MEX 74 / 40 22 / 30 / 5
    MKK 294 / 18 138 / 18 / 0
    TSI 153 / 51 55 / 43 / 4
    YRI 126 / 0 63 / 0 / 0
    1KG A (minor)369 in 2178 = 0.16942 heterozygosity = 0.28143, with SE = 0.24802
    rs1004764 22 38474852 ASW A / G 105 / 9 FET lg p = -89.81

    max diff AF = 0.433
    A/A / A/G / G/G 48 / 9 / 0 intronic: SLC16A8
    CEU 141 / 85 42 / 57 / 14
    CHB 257 / 17 121 / 15 / 1
    CHD 205 / 13 96 / 13 / 0
    GIH 120 / 82 34 / 52 / 15
    JPT 189 / 37 79 / 31 / 3
    LWK 212 / 6 103 / 6 / 0
    MEX 65 / 51 17 / 31 / 10
    MKK 288 / 22 133 / 22 / 0
    TSI 119 / 85 34 / 51 / 17
    YRI 292 / 2 145 / 2 / 0
    1KG G (minor)501 in 2178 = 0.23003 heterozygosity = 0.35423, with SE = 0.22724
    rs1004763 22 38474952 1KG C (minor)742 in 2178 = 0.34068 heterozygosity = 0.44923, with SE = 0.15102 intronic: SLC16A8
    rs2076372 22 38474965 CHB C / T 56 / 34 FET lg p = -8.50

    max diff AF = 0.307
    C/C / C/T / T/T 17 / 22 / 6 intronic: SLC16A8
    JPT 54 / 34 17 / 20 / 7
    YRI 116 / 10 54 / 8 / 1
    1KG T (minor)489 in 2178 = 0.22452 heterozygosity = 0.34822, with SE = 0.22990
    rs2235573 22 38477930 ASW G / A 66 / 46 FET lg p = -8.47

    max diff AF = 0.269
    G/G / A/G / A/A 15 / 36 / 5 exonic: SLC16A8

    synonymous SNV: SLC16A8, NM_013356, exon3, c.C324T, p.L108L
    CEU 113 / 113 25 / 63 / 25
    CHB 129 / 139 33 / 63 / 38
    CHD 97 / 119 25 / 47 / 36
    GIH 145 / 57 51 / 43 / 7
    JPT 117 / 103 30 / 57 / 23
    LWK 132 / 82 40 / 52 / 15
    MEX 70 / 46 21 / 28 / 9
    MKK 203 / 107 63 / 77 / 15
    TSI 104 / 98 28 / 48 / 25
    YRI 170 / 120 46 / 78 / 21
    1KG A (minor)1001 in 2178 = 0.45960 heterozygosity = 0.49673, with SE = 0.04027
    Limited to 5 records in this page. Click here to view more.
  • Genomic Variation --- CNV
  • Data comes from DGV
    Variation IDPositionVar. TypeGainLossTotal GL InvPubMed
    Variation_5185 chr22:38388465-38549017 U E CopyNumber 0 5 5 17160897
    Variation_5186 chr22:38459503-38636510 U E CopyNumber 0 10 10 17160897
  • Haplotype Information
  • Data links to UCSC Genome Browser
    ContentHyperlinkDemo example
    HapMap LD Structure (hg18)UCSC
    1000 Genomes Phase I Haplotype Clustering (hg19)UCSC
    Gene Haplotype Allele (hg19)UCSC
  • ENCODE TFBS (Transcription Factor Binding Sites) Information
  • Epigenetic Information
  • Gene Ontology (GO)
  • Protein Sequence & Features
  • Protein Domain Information
  • Protein-Protein Interaction
  • UniGene EST Expression Data
  • Allen Brain Atlas - Mouse Brain Expression Data
  • RNA-seq Expression Data
  • External Links
  • EntrezGeneID 23539
    Gene Symbol and
    Genome Browser
    SLC16A8
    UCSC Ensembl
    mRNA NM_013356
    protein NP_037488
    Ensembl ENST00000320521; ENSP00000321735; ENSG00000100156
    HPRD 11568
    UniProt Accession O95907
    GeneCards GC22M038474
    UniGene Hs.270285
    HomoloGene 75006
    EMBL AF132610; AF132611; AL031587
    IPI IPI00296004
    PRIDE O95907
    STRING O95907
    TCDB 2.A.1.13.9
    OMIM 610409
    PharmGKB PA38106
    Reactome REACT_111217; REACT_15518; REACT_20633; REACT_604